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Our Platform

Tissue Therapeutics work by allowing us the flexibility to program functional cells and assemble them into Satellites, basic tissue structures that can be introduced into patients to restore, repair or replace dysfunctional or diseased tissue or organs. These Satellites, which enable full leveraging of cells as therapeutic agents, are at the core of our Satellite Adaptive Tissue (SAT) platform.

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The Tissue Seed

The first step in creating a Satellite is to develop the Tissue Seed from a specific combination of highly potent functional cells and support cells, a process we call heterocellular aggregation.

The functional cells can be derived from a number of sources, including primary cells and iPSCs (induced pluripotent stem cells), and importantly lack characteristics of the diseased cells they are designed to replace—from genetic changes, epigenetic changes and other changes that fundamentally alter the functionality and health of these cells.

Through the research of our founders, we have demonstrated that support cells are critical for the stability and effectiveness of functional cells across many mechanisms of action. By using the optimal cell types, seed ratio and cell ratio, we enable persistence and continual function of the Tissue Seeds

Fig. 1 Functional & support cells combine to form Tissue Seeds

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The Satellites

The Tissue Seeds are then encapsulated in a biomaterial-based matrix to create the Satellite. By controlling size and distribution of Tissue Seeds, we can organize precise structures that support a healthy micro-environment for the cells and allow the Tissue Seeds to function effectively and rapidly once in a patient.

The implantable Satellite tissue is an approximately palm-sized disc that allows for the full leveraging of cells as therapeutic agents, marking a significant advancement in the ability of cells to be effectively and successfully delivered into the body to restore, repair or replace damaged tissue or organs. Satellite Bio’s scientists have optimized both the tissue seed aggregate and the bioengineered matrix to allow for seamless vascularization within the body.

Fig. 2 Detail of scalable engineered Satellite

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Delivery Into the Body

The final step in realizing the potential of Tissue Therapeutics is introducing the Satellite into the body. Via minimally invasive surgery, the Satellite is placed in a site within the body. Satellites rapidly promote new blood vessel growth allowing connection to the patient’s own circulation, but operating remotely from the affected tissues. This ability to resolve the underlying function of an organ from a remote location is how Satellites get their name.

Following a diligent mapping of the body—known as the Proprietary SAT-Map—Satellite Bio uniquely understands the specific anatomical placements that enable rapid vascularization with minimal immune impact, thereby optimizing the success of the Satellite.

Fig. 3 Satellite tissues can be implanted within the body via a minimaly invasive procedure

Disease areas of interest

The SAT Platform has the ability to solve elusive diseases across multiple organ types

The potential of the SAT Platform across elusive diseases

The SAT Platform represents an audacious advancement that uses unprecedented cell-based technology with the potential to provide solutions across a broad range of elusive diseases.

The flexibility and bespoke nature of the SAT Platform will allow us to tailor the Satellites to different diseases and individual patient characteristics, providing tangible, sustainable solutions

Initial opportunity to address the needs of patients with elusive diseases of the liver

Liver diseases are associated with significant morbidity and mortality for both hereditary and acquired conditions. Until now, most treatments for these elusive diseases have been focused on disease management or total organ replacement, and advances have yielded limited impact.

Tissue Therapeutics and the SAT platform will usher in an entirely new realm of treatment for liver diseases by introducing proprietary hepatocyte Satellite tissues (HepSAT) that enable hepatocyte engraftment, function and vascularization, leading to long-term repair and restoration of liver function.